Novel optical tool to visualize glycine signalling

Together with the lab of Colin Jackson at the Australian National University in Canberra, we have been able to design, characterize and use the novel optical glycine sensor GlyFS. The full paper can be found here. Using this sensor we could directly show that the levels of the inhibitory neurotransmitter and NMDA receptor co-agonists glycine decrease with postnatal age, increase in response to plasticity-inducing neuronal stimuli and display gradients between synaptic and extrasynaptic locations in the hippocampus.